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With what he calls favourable conditions in the United Arab Emirates, Misbah is aiming to put the Dubai defeat by an innings and 92 runs behind him and hopes Pakistan can exploit the conditions.
"We have been really playing well in one-day cricket in the last three-four years, everybody knows what they are going to get against South Africa and these conditions are always in favour of Pakistan so we are looking forward to playing a good series," said Misbah.
But he warned against complacency as South Africa will be without spearhead bowler Dale Steyn, who is being rested, and Hashim Amla, who returned home as his wife has given birth, for the first two one-day games.
"I always feel that after such news the team gets complacent so if Amla does not play or Steyn doesn't play it doesn't make a difference, South Africa is one of the good teams in the world and have very strong replacements," said Misbah.
Steyn will also miss the second one-dayer, in Dubai on November 1, but is likely to return for the third match in Abu Dhabi on November 6.
The fourth match will also be played in Abu Dhabi, on November 8, before the series ends in Sharjah on November 11.
The two teams will also play two Twenty20 internationals in Dubai on November 13 and 15.
Pakistan will be boosted by the return of all-rounders Mohammad Hafeez and Shahid Afridi, in addition to opener Nazir Jamshed, Umar Akmal and paceman Wahab Riaz.
The Pakistanis won their last two one-day series, against Zimbabwe and the West Indies, while South Africans went down tamely in Sri Lanka 4-1.
But despite that defeat Misbah reckons South Africa are difficult one-day opponents.
"They are a good decent side, they have players who can really turn the matches around, dangerous side so you really need to be on your toes while playing against them," said Misbah, referring to the 3-2 home series defeat the South Africans handed Pakistan in March.
